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NLRP12 protein promotes healthy gut bacteria to curb obesity
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
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Therapeutics
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Green tea compound helps siRNA slip inside cells
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
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Amyloid beta – a good therapeutic target?
Phase III clinical trials for a drug targeting amyloid beta plaques are underway, with results expected in the next two to three years...
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Pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease: approaches and perspectives
Mitochondrial dysfunction has been widely implicated in the neuronal degeneration in Parkinson’s disease (PD). Mitochondria-targeted protective compounds that prevent or minimise a wide range of mitochondrial defects constitute potential therapeutic strategies in the prevention and treatment of neuronal degeneration in PD.
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Np63a should be targeted in squamous cell carcinomas
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
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Structural map of bacterial toxins identified
A three-dimensional structural map of bacterial toxins has been identified for the bacterium Pseudomonas aeruginosa...
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Six compounds identified from 70,000 to help eradicate malaria
Researchers from Imperial College London have identified 6 compounds from almost 70,000 that could help to eradicate malaria...
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CRISPR used to deliver BChE into cells to protect from lethal cocaine doses
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...
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Dietary fibre could be key to prevent age related decline in brain functions
Researchers have identified that dietary fibre could be beneficial for older people, to prevent inflamed microglia leading on to cognitive disorders...
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Fewer side effects from cancer drugs promised
Researchers from Copenhagen have developed a method of accurately using proteins to track the path of a drug through the body to ensure its safety...
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Testosterone replacement therapy could slow the progression of COPD
Researchers from Texas University have used data from men with COPD to ascertain that testosterone replacement therapy could be beneficial...
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Disrupting genetic processes reverses ageing in human cells
Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age...
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Synthetic biology in drug discovery
Synthetic biology is broadly defined as the design and construction of novel artificial biological pathways, organisms or devices; or the redesign of existing natural biological systems.1 It brings together a range of disciplines and skills, from biology and chemistry to computing, bioinformatics and engineering.
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What happens to skin cells when they are confronted with blood?
Researchers have performed experiments on blood-deprived cells that were subsequently exposed to blood serum, revealing new insights into the mechanisms of wound healing...
