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Therapeutics

news

4PY found to directly trigger vascular inflammation

21 February 2024 | By Drug Target Review

Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.

news

Mitigating oxidative stress in neurodegenerative diseases

20 February 2024 | By Drug Target Review

Researchers have found that using protein-like polymers to inhibit the Keap1/Nrf2 PPI is a powerful therapeutic strategy.

news

Oxytocin could mitigate the progression of dementia

14 February 2024 | By Drug Target Review

For the first time, researchers reveal the involvement of OXT in object recognition memory through the supramammillary nucleus.

news

Integrin αV and β5 partner to drive cancer cell growth

7 February 2024 | By Drug Target Review

A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.

news

Advancing the understanding of placenta accreta spectrum disorder

1 February 2024 | By Drug Target Review

A new study has identified targets to refine diagnostic tests, track disease progression, and discover more effective therapies.

news

New insights into the functions of inflammasomes

3 January 2024 | By Drug Target Review

For diseases mediated by NLRP3, AIM2, NLRC4, and Pyrin, understanding inflammasome biology could identify therapeutic targets.

webinar

Advancing therapeutics targeting cytokines with functional cell-based assays

3 January 2024 | By Eurofins DiscoverX

Watch this webinar to discover functional cell-based assays for characterizing novel therapeutics & biosimilars targeting cytokines in inflammation & oncology.

whitepaper

Beyond the lab: RNA

6 December 2023 | By Drug Target Review

Download this exclusive content focusing on new RNA editing technology, the challenges and opportunities presented and the potential of RNA-based therapeutics.

news

New method to develop therapeutics for autoimmune diseases

30 November 2023 | By Drug Target Review

A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.

news

New algorithm identifies a novel CRISPR-Cas system

24 November 2023 | By Drug Target Review

Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.

news

Breast cancer cells invade by a physical mechanism

15 November 2023 | By Drug Target Review

Findings from using a 3D hydrogel to study how cancer cells physically tear the basement membrane offers promise for targeted treatment.

news

Improving ovarian cancer outcomes with artificial intelligence

13 November 2023 | By Drug Target Review

Researchers have developed an AI based model that is 80 percent accurate in predicting the therapy outcome of high-grade ovarian cancer.

Assays for protein degradation therapeutics to accelerate undruggable proteome discoveries

article

Understanding intracellular processes improves LYTACs therapy

7 November 2023 | By Ellen Capon (Drug Target Review)

New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.

news

Microcapsule-loading exosomes to treat vitreoretinal diseases

24 October 2023 | By Drug Target Review

Scientists have developed ExoCaps, self-healing microcapsules that are more feasible than other cell-based technologies.

news

Newly discovered mechanism behind cognitive decline in aging

27 July 2023 | By Izzy Wood (Drug Target Review)

US researchers say new mechanism could lead to new drugs and therapies to treat normal cognitive decline in aging.

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Therapeutics