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Therapeutics

news

Epstein-Barr virus: new targets for vaccine design and treatment

13 March 2024 | By Drug Target Review

A lab generated monoclonal antibody prevented EBV infection and EBV lymphomas in rodent models and could have future clinical applications.

article

Bile acids and the microbiome: revolutionising disease approaches

12 March 2024 | By Ellen Capon (Drug Target Review)

Thousands of bile acids have been discovered, providing new insights into how microbes influence distant organ systems.

news

Recurrent urinary tract infections: potential cause discovered

5 March 2024 | By Drug Target Review

Researchers find that an overgrowth of nerve cells in the bladder could cause rUTIs, which may offer new approaches to manage symptoms.

news

Enhancing the collateral network for beneficial reperfusion

28 February 2024 | By Drug Target Review

Future interventions for ischaemic stroke patients should enhance collateral function to reduce brain haemorrhage and mortality.

article

Mediating BRAF-mutant melanoma resistance

26 February 2024 | By Dr Rhoda M Alani (Boston University Chobanian & Avedisan School of Medicine and Boston Medical Center), Ellen Capon (Drug Target Review)

In this Q&A, esteemed Dr Rhoda Alani discusses the epigenetic landscape of therapy resistant melanomas and elucidates how corin treatment impacts the reprogramming of melanoma cell phenotypes. The findings suggest a new treatment paradigm for melanoma which could also be relevant to targeted therapy resistance mechanisms for other cancer types.

news

4PY found to directly trigger vascular inflammation

21 February 2024 | By Drug Target Review

Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.

news

Mitigating oxidative stress in neurodegenerative diseases

20 February 2024 | By Drug Target Review

Researchers have found that using protein-like polymers to inhibit the Keap1/Nrf2 PPI is a powerful therapeutic strategy.

news

Oxytocin could mitigate the progression of dementia

14 February 2024 | By Drug Target Review

For the first time, researchers reveal the involvement of OXT in object recognition memory through the supramammillary nucleus.

news

Integrin αV and β5 partner to drive cancer cell growth

7 February 2024 | By Drug Target Review

A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.

news

Advancing the understanding of placenta accreta spectrum disorder

1 February 2024 | By Drug Target Review

A new study has identified targets to refine diagnostic tests, track disease progression, and discover more effective therapies.

news

New insights into the functions of inflammasomes

3 January 2024 | By Drug Target Review

For diseases mediated by NLRP3, AIM2, NLRC4, and Pyrin, understanding inflammasome biology could identify therapeutic targets.

webinar

Advancing therapeutics targeting cytokines with functional cell-based assays

3 January 2024 | By Eurofins DiscoverX

Watch this webinar to discover functional cell-based assays for characterizing novel therapeutics & biosimilars targeting cytokines in inflammation & oncology.

whitepaper

Beyond the lab: RNA

6 December 2023 | By Drug Target Review

Download this exclusive content focusing on new RNA editing technology, the challenges and opportunities presented and the potential of RNA-based therapeutics.

news

New method to develop therapeutics for autoimmune diseases

30 November 2023 | By Drug Target Review

A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.

news

New algorithm identifies a novel CRISPR-Cas system

24 November 2023 | By Drug Target Review

Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.

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Therapeutics