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Genes increasing the risk of triple-negative breast cancer identified
Germ line genetic testing analyses blood samples and evaluates inherited genetic changes that increase the risk of certain cancers in an individual...
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Therapeutics
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Reducing NOVA1 helps prevent tumour growth in lung cancer
Researchers have identified a gene that when inhibited, reduced human non-small cell lung cancer tumours from growing...
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CRISPR-Cas9 used to correct sickle cell–causing mutation
Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...
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Novel PET imaging could guide therapy for type 1 diabetes
Since beta cells and neurological tissues have common receptors, researchers screened brain radioligands for their ability to identify beta cells...
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New stem cell model to test treatments for neurodegenerative disorders
The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
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D-PDMP reverses hair loss and skin damage linked to fatty diet
In a series of experiments, researchers have used an experimental compound to successfully reverse hair loss, hair whitening and skin inflammation...
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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IKZF1 gene could improve cancer immunotherapy
A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy...
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CBD improves survival rates of mice with pancreatic cancer
Mice with pancreatic cancer that were treated with CBD alongside chemotherapy, survived almost three times longer than those treated with chemotherapy alone...
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UBR5 protein may reduce neurodegeneration in Huntington’s disease
Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...
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BCX7353 shows hope for hereditary angioedema
A new drug has been developed to help prevent attacks of hereditary angioedema and at the same offer patients a convenient administration...
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Adapting drug discovery to Artificial Intelligence
Drug discovery has always been challenging; today, more so than ever. While there has been success in addressing many diseases, others remain intractable...
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Derm-BOT compound relieves chronic pain
A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects...
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Aggressive Th17 cells aggravate Parkinson’s disease
Researchers identify Parkinson's disease as a possible autoimmune disease...
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Cancer drug screening: the historical perspective
Chemotherapy with cytotoxic and growth inhibitory drugs have played an important role in cancer therapy, used either alone or in combination with other treatment modalities such as surgery, radiation or biological therapy. Chemotherapy, in most instances, was the only alternative treatment for metastatic cancer – mainly given as drug combinations...
