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Expert view: Improving hit-to-lead results
Declining R&D productivity is a key challenge in the pharmaceutical industry today.
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Therapeutics
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours
A study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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GDF6 gene associated with metastatic melanoma
Researchers have revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma...
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Protein associated with ALS points to possible targets for therapeutic intervention
Scientists may have found possible targets for therapeutic interventions in the fight against Lou Gehrig’s disease.
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DNA mutations shed in blood predicts response to immunotherapy
Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...
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Charles River announces success of integrated discovery project with ENYO Pharma
Capture compound mass spectrometry technology enables target identification...
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CXCL5 protein found to stimulate tumour growth in prostate cancer
Researchers identify a pathway that causes tumour acceleration in metastatic prostate cancer cells...
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Study reveals new mechanisms of cell death in neurodegenerative disorders
Researchers have discovered new mechanisms of cell death, which may be involved in debilitating neurodegenerative disorders...
whitepaper
Whitepaper: In search of a disease-modifying agent for Parkinson’s disease: a discovery story
Are selective, brain-penetrant inhibitors of LRRK2 an answer?
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Reducing TIA1 improves nerve cell health in Alzheimer’s disease
Researchers have described a unique model for the biology of Alzheimer's disease which may lead to an entirely novel approach for treating the disease...
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Hindering cadherin-22 may reduce the spread of cancer
Scientists have made a discovery that could reduce the spread of cancer by hindering a protein that binds cancer cells together and allows them to invade tissues...
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Therapeutic target discovered for ER+ breast cancer
Researchers have identified a protein that can be targeted to suppress the growth of a common type of breast cancer...
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ARBs may solve the global antibiotic crisis by 2020
A British biopharmaceuticals company, have developed Antibiotic Resistance Breakers which can restore the original potency against both Gram-positive and Gram-negative bacteria...
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Synthetic T-cells engineered to combat cancer
Researchers have engineered T-cells in the laboratory to combat tumours...
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Ancient antiviral response could help treat cancer
By stimulating a patient’s immune system, a drug already in use to treat a blood disorder can prevent the growth of a variety of solid tumours...
