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Therapeutics

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Scientists identify new treatment for Activated PI3-kinase Delta Syndrome

9 November 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified a new treatment approach for patients with a rare inherited immune disorder...

news

Charles River Laboratories presents newly expanded capabilities at Neuroscience 2017

7 November 2017 | By Charles River Laboratories

Charles River Laboratories International, Inc. announced that its team of neuroscience drug discovery experts is presenting 27 scientific posters, both independently and collaboratively with clients, at Neuroscience 2017, the 47th annual meeting of the Society for Neuroscience (SfN).

news

Theranostic system can eliminate colorectal cancer

3 November 2017 | By Dr Zara Kassam (Drug Target Review)

Three-step pretargeted radioimmunotherapy offers safe and effective treatment for colorectal cancer...

news

Starving a childhood brain tumour of glutamine, may improve the effect of chemotherapy

1 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have shown that starving a childhood brain tumour of the amino acid glutamine may improve the effect of chemotherapy...

news

Charles River announces expansion of in vitro oncology services

30 October 2017 | By Charles River Laboratories

Partnership with InSphero provides additional 3D solutions...

news

KSRP discovery gives a potential therapeutic target to combat trypanosomes

27 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have discovered a new potential therapeutic target – located in the ribosome – to combat trypanosomes parasites...

news

Mature B lymphocytes accelerate the healing of acute and chronic wounds

27 October 2017 | By Dr Zara Kassam (Drug Target Review)

Direct application of immune cells speeds and improves healing of acute and chronic wounds in animal models...

news

Declines in plasticity reveal promising targets for Alzheimer’s disease

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

Brain changes linked to memory loss may provide a new focus for exploring ways to treat or prevent dementia...

news

Self-regulating nanoparticles could treat cancer

24 October 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed 'intelligent' nanoparticles which heat up to a temperature high enough to kill cancerous cells...

news

N-alpha-acetyltransferase D found to promote lung cancer progression

13 October 2017 | By Dr Zara Kassam (Drug Target Review)

NatD, which mediates N-alpha-terminal acetylation of histone H4, found to promote lung cancer progression...

news

Research reveals antibody treatment pathway for severe allergic asthma

13 October 2017 | By Dr Zara Kassam (Drug Target Review)

Blocking the action of two pro-inflammatory molecules can significantly reduce the symptoms of allergic asthma...

Integrated Drug Discovery Panel – Your questions answered!

webinar

Integrated drug discovery panel – your questions answered!

28 September 2017 | By Charles River

During this peer panel discussion, team members from Charles River discussed their views and strategies on Drug Discovery...

whitepaper

Whitepaper: Advancing therapeutic antibody discovery with multiplexed screening

28 September 2017 | By IntelliCyt Corporation

In this whitepaper, IntelliCyt Corporation describe how the iQue Screener is used to perform multiplexed screens for antibody binding to either cell surface or to circulating target antigens...

news

Blocking ApoE4 may prevent nerve cell death in Alzheimer’s disease

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified that the presence of ApoE4 exacerbates the brain damage caused by toxic tangles of tau protein...

news

B-cells promote melanoma progression and resistance to therapy

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...

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Therapeutics