news
Global in vitro toxicology market to grow 8.2 percent
A study has predicted that the global in vitro toxicology market will rise by 8.2 percent in its forecast period.
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Toxicology
article
A high-throughput approach for measuring intracellular ATP levels to access compound-mediated cellular toxicity
Many drugs fail in clinical trials due to toxicity-related issues; therefore, drug-mediated cellular toxicity should be determined at an early stage in the drug discovery value chain. There are many assay systems that can be utilised to measure cellular toxicity. In this article we demonstrate that intracellular ATP concentrations are…
article
Expert view: Large‑scale stem cell expansion and differentiation
Stem cell-based technologies lay the basis for pioneering approaches in drug screening, toxicology testing, and regenerative medicine. The constant supply of high cell numbers in consistent quality needs scalable culture systems and standardised process conditions.
whitepaper
Whitepaper: Opportunities in preclinical development
This whitepaper explains how you can find ways to optimise the holistic preclinical development process...
article
Genomics in drug development and safety testing; from target identification to genomic toxicology
In the annual report of the Chief Medical Officer, 1 Dame Sally Davies has declared that we are part of ‘generation genome’ – the era in which we reap the rewards of our advances in genomic technologies and improvements in our understanding of the whole genome in human health.
news
SMi’s 13th Annual ADMET conference 2018 brochure released
The annual ADMET conference is returning to London, UK for its 13th year running and will be taking place at the Holiday Inn Kensington Forum on the 9 and 10 July 2018...
article
Expert view: Conquering late stage failures with advanced hit-to-lead techniques
Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.
article
Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
news
Prenatal exposure to BPA at low levels can affect gene expression
Prenatal exposure to BPA affects gene expression related to sexual differentiation and neurodevelopment in the developing brain...
news
New botulinum neurotoxin discovered
Researchers have identified a new toxin, botulinum neurotoxin type X (BoNT/X), that has the potential to open up a new field of toxin therapeutics...
news
Balance and movement improved in animal model of Parkinson’s disease
Researchers have developed a molecular compound that improves balance and coordination in mice with early stage Parkinson's disease.
webinar
The mast cell receptor MrgX2 and drug-induced anaphylaxis
10 May 2017 | By DiscoverX
The goal of this webinar is to illustrate how knowledge of MrgX2 activity across a panel of mammalian species can be integrated into drug development to influence choice of compound, species model and dosing regimen...
news
Novel method to detect toxic effects of chemicals could reduce need for animal testing
Traditional toxicological investigations performed on animals (in vivo) are expensive, time-consuming and may cause animal suffering.
news
Sound Pharmaceuticals receives $1.6 Million Award to treat CF-related tinnitus
Sound Pharmaceuticals has been awarded up to $1.6M from Cystic Fibrosis Foundation Therapeutics (CFFT), the non-profit drug discovery and development affiliate of the Cystic Fibrosis Foundation.