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Is an HIV vaccine on the horizon?
Researchers in the US have developed a potential HIV vaccine approach that aims to prompt the creation of broadly neutralising antibodies via mRNA.
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Translational Science
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Molecular Devices and HeartBeat.bio announce collaboration to automate and scale cardiac organoids for high-throughput screening in drug discovery
Molecular Devices has announced a collaboration with HeartBeat.bio to develop cardiac organoids for use in drug discovery.
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Drug Target Review – Issue 2 2022
In this issue are articles focusing on a novel stem cell therapy for hearing loss, how a non-linear chiroptical effect could aid drug discovery and the advantages of cryo-electron tomography for imaging research. Also included are pieces on gene therapy, spheroids and genomics.
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New immune targets to improve survival from sepsis
References for ‘New immune targets to improve survival from sepsis’, in Drug Target Review Issue 2 2022.
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Improving Huntington’s disease drug discovery with new reproducible disease models
27 May 2022 | By bit.bio
This webinar explores how a new generation of reproducible and scalable human cell models are being utilised for drug discovery in Huntington’s disease.
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A three-dimensional model for rare neuromuscular disorders
Scientists have created a tiny, bioengineered 3D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.
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Novel technique to rapidly find prostate cancer drugs
A new screening assay could be used to identify new drugs to treat resistant forms of prostate cancer.
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New genetic model of Down’s syndrome developed in rats
Scientists have created what they believe is the first rat model of Down’s syndrome. The animal model shares features with human Down’s syndrome, which will allow for efficient testing of new therapies.
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“Monumental” step in using human iPSCs towards treating complication of diabetes
A new study led by the Indiana University School of Medicine showed human induced pluripotent stem cells can improve visual acuity, vascular health and other complications related to type 2 diabetes.
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Pre-clinical models of endometriosis and their value for translational research
In this exclusive Q&A, Dr Paulina Nunez-Badinez, Scientific Researcher at Bayer AG, discusses pre-clinical research of pain related to endometriosis and why there is a lack of research around this area.
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Cannabidiol analogue could enhance chemotherapy by preventing neuropathic pain
A new study has revealed a cannabidiol analogue can possibly prevent neuropathic pain induced by chemotherapy, as well as being beneficial against cancer.
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New pre-clinical study demonstrates innovative approach to treating brain diseases
Researchers have been able to slow down the progression of glioblastoma in mice, the most common adult brain cancer.
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Bone marrow stem cell transfusions show promise as potential treatment for sepsis
New research has shown that one-time infusion of stem cells from bone marrow improves the survival of mice with sepsis.
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Tweaked bacteria genes activate heart cells in mice
Researchers have shown that engineered bacterial genes coding for sodium ion channels could lead to novel gene therapies for electrical heart diseases.
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Researchers identify potential drugs to reduce COVID-19 mortalities
Researchers have established a list of compounds that effect cytokine storms that could reduce mortality in COVID-19 patients.