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Translational Science
article
Supporting the progression of phenotypic hits with bioactivity profiling
Bioactivity profiling has been traditionally used to assess the selectivity of new drug candidates in the context of target-based approaches, where pharmacological selectivity is a key requirement.
whitepaper
Tech note: Long term live cell imaging in a high-content system
How to perform successful long term live cell imaging in a high-content analysis system.
webinar
Transforming translational research: CANscriptTM – A better predictive model for oncology
27 April 2018 | By Mitra Biotech
In this webinar, speaker Mark Paris, PhD discussed a recent study evaluating a cohort of HNSCC patient tumours treated with anti-PD1 using CANscript TM;. He also be reviewed the results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resistance.
webinar
Automated assessment of Liver and Cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays
27 April 2018 | By TECAN
ABOUT THIS WEBINAR: In this two-part webinar, both automation of P450 (CYP) assays and the automatisation of cellular differentiation processes and compound testing using human induced pluripotent stem cells based assays was covered. Metabolism of drugs is a key factor in compound toxicity, and automated assays which monitor inhibition or…
webinar
Using bioactivity profiling to support the progression of phenotypic hits
27 April 2018 | By Eurofins Pharma Discovery Services
In this webinar, we discussed a recent case study where a phenotypic screen was performed using poly I:C / IL-4 stimulated human bronchial epithelial cells. This resulted in the identification of 7 representative hits which provided starting points for new drug discovery opportunities.
news
The National Institutes of Health announce Biobanking Medical Project
SMi Reports: The National Institutes of Health announce one of the most ambitious medical projects in biobanking, which will commence this spring.
article
Expert view: Laboratory informatics software – the top challenges
A look back, and forward, at the key trends within laboratory informatics.
whitepaper
Case Study: Characterisation of hiPSCs by Phenotypic Screening
Case study detailing a simple, highly reproducible phenotypic screen to characterise human induced pluripotent stem cells...
product
Operetta CLS High-Content Analysis System
6 February 2018 | By PerkinElmer
Operetta CLS is a high-content cell analysis system featuring a unique combination of technologies to deliver high speed, sensitivity, and resolution...
product
JANUS® G3 automated workstation
26 January 2018 | By PerkinElmer
The JANUS G3 automated workstation offers multiple pipetting technologies on a single instrument platform.
whitepaper
Whitepaper: Phenotypic drug discovery with high content screening
Reasons for phenotypic vs. target based drug discovery strategies, challenges of and maximising return of phenotypic assays.
whitepaper
Application note: Distinguishing cell types by phenotypic profiling
Describing how a single nuclear stain can enable phenotypic profiling for new and additional perspectives on assays at no extra cost.
whitepaper
Tech note: Benefits of water immersion lenses for HCS
Water immersion lenses provide: brighter images from HCS samples; faster and gentler imaging; higher quality images from both 2D and 3D samples.
