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Newly discovered SARS-CoV-2-like virus could infect humans and resist vaccines
A recently discovered SARS-CoV-2 virus in a Russian bat is likely to be capable of infecting humans and resistant to current vaccines.
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Drug Target Review – Issue 3 2022
In this issue are articles on synthetically engineered bacteria to deliver therapeutics, how single-molecule fluorescence resonance energy transfer was used to image GPCRs and a new assay to identify coronavirus drugs. Also included are pieces on vaccine development, monoclonal antibodies and neuroscience.
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Advancing vaccines with extracellular vesicles
References for ‘Advancing vaccines with extracellular vesicles’, in Drug Target Review Issue 3 2022.
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New findings could lead to a vaccine that can offer protection against emerging COVID-19 variants
Scientists have discovered antibodies that are effective against many different COVID-19 variants.
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Universal flu vaccine protects against influenza A and B viruses
Vaccinating mice with this universal flu candidate induced broad neuraminidase inhibition, M2 ectodomain specific antibodies and T cell immune responses.
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How to tackle the immense challenge of delivering vaccines
Researchers have developed a safe and versatile platform to increase the thermal stability of vaccines and improve their transportability.
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New generation of COVID-19 vaccines show promising results
Researchers have designed a COVID-19 vaccine to be less sensitive to mutations and equipped for future strains.
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A modified TB vaccine could treat bladder cancer
An animal study has shown that a modified vaccine for tuberculosis could treat bladder cancer whilst minimising side effects.
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Genomic studies could impact pneumococcal disease vaccine design
A recent genomic surveillance study has demonstrated the value of genomics to inform vaccine design and highlight the challenge posted by shapeshifting bacteria.
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New vaccine protects mice against RSV
The new RSV vaccine formulation protected newborn mice against infection and evoked strong responses in immune cells from human newborns.
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Targeted cancer vaccines eliminate tumours and prevent recurrence in mice
Researchers have developed an mRNA-based cancer vaccine that is delivered directly into the lymphatic system for a more potent response.
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New needle-free nasal vaccine shows promise for COVID-19
Researchers have developed a needle-free mucosal bacteriophage (phage) T4-based COVID-19 vaccine is effective against SARS-CoV-2 infection.
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Nanoparticle vaccine protects against a range of COVID-19 variants
The vaccine attaches spike proteins from SARS-CoV-2 and seven other SARS-like betacoronaviruses to a protein nanoparticle structure, to induce the production of a broad spectrum of cross-reactive antibodies.
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Scientists develop effective intranasal mumps-based COVID-19 vaccine candidate
The researchers used a modified live attenuated mumps virus for delivery, showing that a more stable coronavirus spike protein stimulates a stronger immune response, and suggesting a dose up the nose has an advantage over a shot.
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Promising developments in quest to design pan-coronavirus vaccine
Researchers have shown that a specific area of the SARS-CoV-2 spike protein is a promising target for a pan-coronavirus vaccine that could offer some protection against new virus variants, common colds, and help prepare for future pandemics.