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How successive mRNA vaccines shape T-cell memory
A new study shows that changes in clonal dominance characterises T-cell memory against multiple COVID-19 variants following mRNA vaccinations.
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Virology
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New insights into viral-related myocarditis
Understanding heart changes at the molecular level during early infection with adenovirus could enable identification of those at higher risk of arrhythmia.
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Identification of antibodies to target the NA globular head domain
The study's findings could be applied to the development of new vaccine and therapeutic strategies for influenza.
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Combatting HIV using gene therapy
Researchers have created a nanomedicine loaded with siRNAs, which demonstrated a 73 percent reduction in HIV replication.
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The molecular mechanisms of lenacapavir revealed
Researchers discover a mechanism that could be exploited for targeting other viruses that build capsids to hide from host defences.
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SARS-CoV-2 viral peptide fragments cause serious inflammatory response
In this Q&A, Dr Gerard Wong elucidates the inflammatory capacity of fragmented viral components from the perspective of supramolecular self-organisation.
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Microbiota composition influences respiratory virus susceptibility
The interactions linking intestinal microbiota with the functionality of basally resident alveolar macrophages and severity of infection are revealed.
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How the HIV capsid has evolved into a molecular transporter
The discovery that HIV capsids are importin-like transporters could be exploited for improved AIDS therapies.
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The promise of nanobodies to neutralise the human norovirus
A new discovery about the dynamic structure of norovirus particles has implications for vaccine development.
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Mechanism discovered that enables TB persistence in humans
One gene involved in the production of iron-sulphur clusters may be crucial for the persistence of Mycobacterium tuberculosis.
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Potential therapeutic target found for the Zika virus
A discovery about Zika’s enzyme, NS2B-NS3, offers promise for therapeutic targets for Zika and other flaviviruses.
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New detection system for viral infections helps vaccine and drug development
Out of the US, a newly developed a rapid, stain-free, and automated viral plaque detection system enabled by holography and deep learning, is a cost-effective way of observing the formation of viral plaques caused by viral infections over a layer of cells.
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Measles virus can develop mutations that cause fatal SSPE
Japanese researchers find a new mechanism for how the measles virus can cause a rare but fatal neurological disorder: subacute sclerosing panencephalitis (SSPE).
