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X-ray Crystallography

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Researchers discover mechanism behind severe cases of G6PD deficiency

20 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have revealed how the most severe cases of G6PD deficiency occur, which could help scientists design new drugs for the disease.

article

The latest pre-clinical HIV vaccine developments

25 November 2020 | By Victoria Rees (Drug Target Review)

This article lists three of the most recent advances in pre-clinical HIV research and vaccine development.

article

Acquiring structural data on membrane proteins – a spotlight on GPCRs

17 November 2020 | By Victoria Rees (Drug Target Review)

Lan Zhu from Arizona State University explains how cryo-EM methods can be used to obtain structural information on membrane proteins such as GPCRs.

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X-rays reveal structure of SARS-CoV-2 protease at room temperature

29 June 2020 | By Victoria Rees (Drug Target Review)

Researchers grew large crystals and used an X-ray machine with a less intense beam to elucidate the structure of the SARS-CoV-2 main protease at room temperature.

Coronavirus particles in green with purple extracellular proteins

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Preliminary SARS-CoV-2 protease inhibitor shows efficacy in mice

20 March 2020 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography, researchers have revealed the structure of the SARS-CoV-2 main protease, designing an inhibitor to bind to this target and prevent viral replication.

computer model of a cell membrane lipid bilayer with receptors, proteins and carbohydrates

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Artificial binding protein could be developed into a novel anti-viral or cancer therapy

18 March 2020 | By Hannah Balfour (Drug Target Review)

Scientists have created an artificial protein able to recognise and bind cell surface carbohydrates with high affinity and selectivity.

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Researchers image C. diff toxins to aid in drug design

3 January 2020 | By Victoria Rees (Drug Target Review)

A new study has used several imaging techniques to characterise C. diff toxins, which could help to design drugs to combat infections from the bacteria.

article

Advances in mass spectrometry: unlocking the potential of chemical crosslinking as a structural biology tool

16 December 2019 | By Professor Albert JR Heck Utrecht (University and the Netherlands Proteomics Centre), Professor Alexander Makarov (Thermo Fisher Scientific), Professor Henning Urlaub (Göttingen University Medical Center), Professor Vicki Wysocki (Ohio State University)

Chemical crosslinking coupled with mass spectrometry (XL-MS) has been used for many years to study protein structure and function. However, recent advances in MS technology, as well as crosslinking reagents and data analysis tools, mean the technique has truly come of age. Here, Albert JR Heck, Alexander Makarov, Henning Urlaub…

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Protein imaging equipment enables enzymes to be observed in real-time

19 November 2019 | By Rachael Harper (Drug Target Review)

The imaging equipment, European XFEL, is said to mark a new age of protein movie-making and enables enzymes involved in disease to be observed in real-time.

article

The promise and pitfalls of serial femtosecond X-ray crystallography

4 September 2019 | By Victoria Rees (Drug Target Review)

A report from scientists at the Moscow Institute of Physics and Technology highlights the advantages and disadvantages of serial femtosecond X-ray crystallography. This article investigates the review, focusing on its role in drug development.

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Scientists achieve the first stable simulations of DNA crystals

21 January 2019 | By Drug Target Review

A study by researchers at the Institute for Research in Biomedicine has been the first to achieve stable simulations of DNA crystals...

news

PARK14 protein associated with inflammation in Parkinson’s

15 March 2018 | By Dr Zara Kassam (Drug Target Review)

Study overturns previous ideas about enzyme linked to many illnesses

news

Studying mitosis’ structure to understand the inside of cancer cells

19 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have uncovered the architecture of the spindle pole body in yeast...

news

DNMT3A crystal structure linked to cancer development

12 February 2018 | By Drug Target Review

Scientists offer important information for understanding de novo DNA methlylation...

news

DRD2 crystal structure provides antipsychotic drug development tool

26 January 2018 | By Dr Zara Kassam (Drug Target Review)

Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...

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X-ray Crystallography