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X-ray Crystallography

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A2aAR protein holds clues for better drug design

2 January 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...

news

Potential therapeutic protein inhibitors for Chagas disease

26 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...

article

Imaging In-Depth Focus 2017

11 September 2017 | By Drug Target Review

This In-Depth Focus explores current uses and future development in mass spectrometry imaging for bringing new drugs to market...

article

Drug Target Review – Issue #3 2017

6 September 2017 | By Drug Target Review

Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...

news

University of Maryland opens new imaging centre

15 June 2017 | By Niamh Marriott (Drug Target Review)

University of Maryland Charles Regional Medical Centre have opened a new outpatient imaging centre in partnership with two other organisations.

news

€3.3 million to improve medical imaging detail tenfold

3 November 2016 | By Niamh Louise Marriott, Digital Content Producer

A recent investment of €3.3 million will allow researchers to improve the detail of medical imaging ten times over, which will allow for tumour scanning...

news

Heptares and leadXpro to employ powerful new techniques for GPCR structure determination

29 June 2016 | By Victoria White, Digital Content Producer

Heptares Therapeutics and leadXpro are to employ powerful new approaches for the determination of high-resolution X-ray structures of GPCRs...

news

Snapshots of the NMDA receptor could aid drug development

3 May 2016 | By Victoria White, Digital Content Producer

Researchers have obtained images of the NMDA receptor in different states. Understanding how NMDA receptors activate is critical in designing new drugs...

news

New nerve agent antidotes in sight, say researchers

3 May 2016 | By Victoria White, Digital Content Producer

The deadly nerve agent sarin can be stopped if treated with an antidote. Now, a new study describes how such a drug works...

news

Zika virus structure revealed by Purdue scientists

1 April 2016 | By Victoria White

Researchers have determined the structure of the Zika virus, revealing insights critical to the development of effective antiviral treatments and vaccines...

news

Scientists show how drug molecules regulate β2AR

11 December 2015 | By Victoria White

A new study shows how different pharmaceutical drugs hit either the "on" or "off" switch of β2AR - signalling protein linked to asthma, obesity and type 2 diabetes...

news

ICR identify Brf2 as a potential target for future cancer drugs

4 December 2015 | By Victoria White

ICR scientists have discovered Brf2 acts as a ‘master switch’ within cancer cells that seems to override the normal stress response...

news

Scientists use X-ray crystallography to see pneumolysin

24 November 2015 | By Victoria White

Pneumolysin is associated with deadly infections such as bacterial pneumonia, meningitis and septicaemia...

news

Major advance towards long-lasting universal influenza vaccine

25 August 2015 | By Victoria White

Scientists from The Scripps Research Institute (TSRI) and Janssen have found a way to induce antibodies to fight a wide range of influenza subtypes...

news

Researchers discover adhesive strategy of H. pylori

17 August 2015 | By Victoria White

Researchers from have identified the molecular mechanism that an adhesion protein of H. pylori uses to attach to stomach ulcers...

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X-ray Crystallography