Solving the AOC puzzle: Strategies for chemistry, manufacturing and regulatory success
Supported by:
14 May 2025
3:30pm
Shares
- Like
- Digg
- Del
- Tumblr
- VKontakte
- Buffer
- Love This
- Odnoklassniki
- Meneame
- Blogger
- Amazon
- Yahoo Mail
- Gmail
- AOL
- Newsvine
- HackerNews
- Evernote
- MySpace
- Mail.ru
- Viadeo
- Line
- Comments
- Yummly
- SMS
- Viber
- Telegram
- Subscribe
- Skype
- Facebook Messenger
- Kakao
- LiveJournal
- Yammer
- Edgar
- Fintel
- Mix
- Instapaper
- Copy Link
Join our webinar with Abzena’s experts to explore practical solutions for overcoming chemistry, manufacturing and regulatory challenges in antibody-oligonucleotide conjugate (AOC) development, enabling progress for previously untreatable diseases.
Join our expert-led webinar to explore critical challenges in developing and manufacturing antibody-oligonucleotide conjugates (AOCs). These innovative therapies hold transformative potential for previously untreatable diseases, but their complexity requires specialised strategies to ensure success.
Successfully developing AOCs is not straightforward, as significant complexities involving sequence fidelity, conjugation stability and impurity management can hinder progress. Additionally, finding an experienced development partner with proven expertise in protein engineering, oligo chemistry and bioconjugation strategies can be challenging.
In this webinar, join Dr Stephen Verespy, Scientific Leader, and Dr Jeffrey Mocny, Vice President of Regulatory Strategy at Abzena, as they directly address key issues in AOC development. Gain actionable insights and practical strategies to overcome chemistry, technical and regulatory hurdles, helping you achieve greater success in your AOC programmes.
Key learning points:
- Explore the unique chemical complexities of integrating antibody and oligonucleotide components into effective, manufacturable AOCs.
- Gain practical insights into oligo synthesis techniques and bioconjugation strategies.
- Understand key differences between AOCs and ADCs, focusing on payload complexity, impurity profiles, and essential analytical methods.
- Navigate the evolving regulatory landscape, including considerations around impurity control, stability, immunogenicity, and defining clear target product profiles.
Register your details now >>>
OUR SPEAKERS
Dr Stephen Verespy – Scientific Leader, Abzena
Dr Stephen Verespy earned his PhD in Chemical Biology from Virginia Commonwealth University at the Center for Drug Discovery and completed and completed postdoctoral training in Chemical Glycobiology at the University of California, San Diego. He brings extensive expertise in small molecule organic synthesis, linker design and synthesis, and bioconjugation, specifically focusing on ADCs, glycans, oligonucleotides, and peptide conjugates. Verespy currently serves as Director of the Scientific Office at Abzena, leveraging his substantial experience – including six years at a San Diego-based biotech, where he most recently led bioconjugation and chemistry initiatives.
Dr Jeffrey Mocny – VP of Regulatory Strategy, Abzena
Dr Jeffrey C. Mocny joined Abzena in early 2022 as Scientific Lead for Product Strategy, Regulatory Strategy, Quality Management, and Product Development, based at their Bristol, PA facility. Before joining Abzena, Mocny served as Senior Vice President of Regulatory Affairs at ProEd Regulatory, a medical communications and strategy agency. With over three decades of experience in drug development and regulatory strategy, Mocny has extensive expertise guiding programs from concept to completion across biotechnology, nutraceutical, and pharmaceutical industries.
FAQs
Is the webinar free?
Yes – there is no charge to watch the webinar, either live or on-demand.
When will the webinar take place?
The webinar will take place live on 14 May at 4:30pm BST.
I’m busy. Can I watch it later?
The webinar will become available to watch on-demand shortly after the live webinar takes place.
What are the benefits of attending live?
During the live webinar, you’ll be able to ask the speakers your questions, which will then be answered during the live Q&A session towards the end of the webinar.
How long will the webinar be?
This webinar will last for up to one hour.
What do I need to watch this webinar?
All you need is a computer with an internet connection. Be sure to use headphones if in an office environment.
Do I receive a certificate?
Yes, you will receive a certificate if you attend the webinar live. The certificate will be sent with your on-demand video link.
