Hit discovery for GPCRs: HTS or virtual screens?

Carleton Sage, Vice President, Computational Sciences

Dr Carleton Sage is the Vice President of Computational Sciences at Beacon Discovery. He has over 24 years of drug discovery experience in the biotech industry, most recently at Arena Pharmaceuticals where he was a Research Fellow in Computational Systems. There, he helped develop and apply novel computational approaches to GPCR drug discovery projects that led to more than a dozen molecules which entered pre-clinical and clinical development.

As a post-doctoral fellow, Dr Sage worked to elucidate the catalytic mechanism of Thymidylate Synthase (TS) and identify novel inhibitors of this anticancer target through a collaboration with Arris Pharmaceuticals focused on using novel computational methods. He went on to MetaXen, where he provided computational support to drug discovery projects and contributed to the development of novel algorithms for the prediction of ADME properties. He became Group Leader of Computational Sciences at Lion Biosciences, where he developed structure-based ADME prediction tools.
Dr Sage obtained his PhD in Biochemistry and Molecular Biology from the University of California, Santa Barbara.