A microplate-based method for the determination of association and dissociation rate values in high throughput using a kinetic probe competition assay (kPCA).
Many biological processes are driven by the interaction of two molecules. Enzymatic reactions, protein-protein binding, DNA replication or receptor-ligand interactions are just a few examples that inevitably depend on the proximity of two binding partners and their binding affinity to each other. To induce their effect, drugs are often specifically designed to target molecular interactions associated with specific diseases. Accordingly, the efficacy and safety of drug candidates depends on their affinity with their targets.
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