Product hub: Why automation is outpacing traditional methods for single-cell cloning

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Genetic modification of mammalian cells has a breadth of use in biotherapeutics development and basic research applications. An important step early on is the isolation of clones with the desired mutation prior to downstream analysis. While fluorescence-activated cell sorting (FACS) and limiting dilution have traditionally been the methods of choice, many are turning to automated, image-based solutions.

Read the following article where we cover:

• The importance of monoclonality
• What is limiting dilution?
• Additional requirements in cell line development
• Image-based systems for single cell isolation.

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