This ebook summarizes the basics of Fc receptor function and discusses biochemical and cell-based assays that enable antibody optimization projects.
Interactions between antibody drugs and Fc Receptors impact therapeutic efficacy. The development of new therapeutic antibodies (which are mostly IgGs) may require optimization of their interaction with FcRn or with the appropriate FcγR. Scientists must choose cell models and assays carefully depending on their intended goal. This ebook summarizes the basics of Fc receptor function and discusses biochemical and cell-based assays that enable antibody optimization projects.
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