Article: Immuno-oncology: Pushing the frontier of discovery through advanced high throughput flow cytometry
Immuno-oncology (IO) is increasingly prized as an effective therapy in cancer management.
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Whitepapers
Application note: A kinase inhibitor phenotypic screen using a multiplex T Cell activation assay
Modulating the TCR signaling pathway using biologics, small molecules or genetic engineering is highly relevant to many therapeutic areas including cancer immunotherapy, adoptive cell therapy, vaccine development and autoimmune disease.
ebook: The definitive guide to understanding protein stability
Learn how to measure protein stability, why it’s important, and what the key technologies are available to measure it.
Whitepaper: Virus-laden particle detection in the air
Read application notes and best practices for optimised environmental detection and monitoring of airborne viruses with Coriolis® Air Samplers.
Whitepaper: Optimised homogenisation for virus studies
Best practices and optimised protocols with Precellys for high throughput sample preparation related to virus studies.
Application note: High-throughput pathogen detection using a novel MagMAX kit and OpenArray technology
Automated detection and isolation of pathogens for multiple samples types.
Application note: Sensitive detection of viral nucleic acids
A simple and sensitive method for nucleic acid extraction from virus-containing samples, with a range of viral loads.
Application note: Metagenomic analysis of the human microbiome
Isolate high-quality, inhibitor-free DNA and RNA from human stool and other sample types suitable for metagenomics sequencing.
ebook: How FBDD improves hit rates & delivers high-value targets
Learn how fragment-based drug discovery improves hit rates and delivers higher-value targets using various biophysical methods.
Guide: Five ways biophysical tools help brain studies
Learn why researchers turned to biophysical methods to expose the molecular mechanisms of neurodegenerative diseases.
Application note: CRISPR-Cas9 screening for target identification
The identification and validation of novel drug targets is a challenging process for drug discovery programmes.
Application note: High-throughput sialylation screening in combination with titer monitoring for expediting clone selection in cell-line development
Glycosylation is one of the most important post-translational modifications when developing new biologics. It has a considerable impact on product performance and variability and is therefore a critical quality attribute (CQA), influencing product safety and efficacy.
Application note: Monitoring of SMALP-nanodisc formation by microfluidic diffusional sizing
29 May 2020 | By Fluidic Analytics
Styrene–maleic acid (SMA) copolymers have become popular tools used in membraneprotein research as they can extract both lipids and membrane proteins from cellular membranes while preserving the bilayer structure of the membrane in so-called nanodiscs.
Application note: Improvement of bovine parainfluenza 3 virus production yields and capacities using the Corning® HYPERFlask® cell culture vessel
Parainfluenza 3 (PI3V) is a virus that causes respiratory diseases in calves, from the common cold to advanced pneumonia.
Application note: Screening for optimal association and dissociation rates of ligands using a live cell binding assay
Potential drugs not only need to bind to their targets, they also need to remain bound for a specific amount of time in order to work efficiently.