Application note: Performing NanoBRET with the Varioskan LUX multimode reader
In this paper, Thermo Fisher Scientific aim to assess the performance of Thermo Scientific Varioskan LUX when running NanoBRET.
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Whitepapers
Application note: Screening for inhibitors of PD-1 and PD-L1 binding with AlphaLISA technology
In this application note, PerkinElmer demonstrate the utility of an AlphaLISA assay for screening biotherapeutic antibodies and compounds that block binding of human PD-1 and PD-L1.
Application note: KingFisher sample purification system
Next generation sequencing sample preparation on the KingFisher platform...
Scientific article: iPSC Cells
An entirely new area of stem cell biology was introduced by Shinya Yamanaka in 2006 when he discovered that somatic cells could revert back to pluripotent-like cells, or induced pluripotent stem cells (iPSCs).
Whitepaper: In search of a disease-modifying agent for Parkinson’s disease: a discovery story
Are selective, brain-penetrant inhibitors of LRRK2 an answer?
Whitepaper: Automatic calculation of HeLa cell culture confluency
Cell confluency is a key parameter for all cell biologists as it is the beginning of all other cell culture experiment such as transfection, cell-based assays and cell culture quality control...
Whitepaper: Advancing therapeutic antibody discovery with multiplexed screening
In this whitepaper, IntelliCyt Corporation describe how the iQue Screener is used to perform multiplexed screens for antibody binding to either cell surface or to circulating target antigens...
Application note: Multiplexed detection of mouse cytokines using QBeads and the iQue Screener
This application note illustrates the value of multiplexing, rapid sampling, and assay miniaturisation using QBeads on the iQue Screener...
Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity
In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...
Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
Application note: KingFisher Presto sample purification system
In this application note Thermo Fisher Scientific compare data from the KingFisher Flex and KingFisher Presto instruments. Our results clearly indicate that the instruments produce equivalent yields and quality of extracted products. DNA extraction from human whole blood is shown as an example...
Application note: Characterising chemokine receptor inhibitors with Alpha SureFire Ultra assays
In this application note, PerkinElmer discuss how their ValiScreen CXCR2 GPCR cell line (#ES-145-C) was utilised to examine the downstream effects of chemokine receptor modulation using multiple blocking antibodies and a small molecule...
Paper: Acquisition and reversal of visual learning in CVN mice
Peer-reviewed paper on how touchscreen testing is a translational tool to assess cognitive function in a mouse model of Alzheimer’s disease...
Review: Protein misfolding in neurodegenerative diseases
Peer-reviewed publication on new strategies to target misfolded protein aggregates at various steps of protein production and processing...
Application note: The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid handler
In this application note, Sheraz Gul (Fraunhofer-IME SP), Markus Wolf (Fraunhofer-IME SP), Enda O’Connell (National University of Ireland Galway) and Howard Fearnhead (National University of Ireland Galway), demonstrate that the Echo 550 Liquid Handler can precisely and accurately transfer nanolitre volumes of compound with acoustic energy in a completely contact-free…